人 KRT8 (NM_002273) cDNA克隆

基本信息

Accession: NM_002273
基因名称: KRT8
基因别名: K8; KO; CK8; CK-8; CYK8; K2C8; CARD2
基因描述: Homo sapiens keratin 8 (KRT8), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1452 (查看编码区序列)
翻译后氨基酸长度: 483 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation in a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform 2.

订购信息

产品编号 产品名称 载体 规格 价格
G108964 人 KRT8 (NM_002273) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 KRT8 (NM_001256282) cDNA克隆 transcript variant 1
人 KRT8 (NM_002273) cDNA克隆 transcript variant 2
人 KRT8 (NM_001256293) cDNA克隆 transcript variant 3

基因简介

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

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