This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
人 MTHFD2 (NM_006636) cDNA克隆
| Accession: | NM_006636 |
|---|---|
| 基因名称: | MTHFD2 |
| 基因别名: | NMDMC |
| 基因描述: | Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2), transcript variant 1, mRNA. |
| 种属: | Human |
| CDS区长度: | 1053 (查看编码区序列) |
| 翻译后氨基酸长度: | 350 (查看氨基酸序列) |
| Transcript Variant: | This variant (1) represents the shorter transcript and is the protein-coding transcript. |
| 人 MTHFD2 (NM_006636) cDNA克隆 | transcript variant 1 |
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