人 VPS72 (NM_001271088) cDNA克隆

基本信息

Accession: NM_001271088
基因名称: VPS72
基因别名: YL1; CFL1; Swc2; YL-1; TCFL1
基因描述: Homo sapiens vacuolar protein sorting 72 homolog (S. cerevisiae) (VPS72), transcript variant 3, mRNA.
种属: Human
CDS区长度: 600 (查看编码区序列)
翻译后氨基酸长度: 199 (查看氨基酸序列)
Transcript Variant: This variant (3) uses two alternate splice sites in the 3' coding region that result in a frameshift, compared to variant 1. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G110281 人 VPS72 (NM_001271088) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 VPS72 (NM_001271087) cDNA克隆 transcript variant 1
人 VPS72 (NM_005997) cDNA克隆 transcript variant 2
人 VPS72 (NM_001271088) cDNA克隆 transcript variant 3

基因简介

The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

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