人 CXCR3 (NM_001142797) cDNA克隆

基本信息

Accession: NM_001142797
基因名称: CXCR3
基因别名: GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
基因描述: Homo sapiens chemokine (C-X-C motif) receptor 3 (CXCR3), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1248 (查看编码区序列)
翻译后氨基酸长度: 415 (查看氨基酸序列)
Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in an isoform (2, also known as CXCR3-B) with a longer and distinct N-terminus compared to isoform 1. This isoform acts as functional receptor for chemokine CXCL4/PF4 (PMID:12782716).

订购信息

产品编号 产品名称 载体 规格 价格
G110334 人 CXCR3 (NM_001142797) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CXCR3 (NM_001504) cDNA克隆 transcript variant 1
人 CXCR3 (NM_001142797) cDNA克隆 transcript variant 2

基因简介

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

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