人 RNF34 (NM_001256858) cDNA克隆

基本信息

Accession: NM_001256858
基因名称: RNF34
基因别名: RFI; RIF; RIFF; hRFI; CARP1; CARP-1
基因描述: Homo sapiens ring finger protein 34, E3 ubiquitin protein ligase (RNF34), transcript variant 3, mRNA.
种属: Human
CDS区长度: 543 (查看编码区序列)
翻译后氨基酸长度: 180 (查看氨基酸序列)
Transcript Variant: This variant (3) has multiple differences in the 5' coding region which results in the use of an alternate translational start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to variant 1.

订购信息

产品编号 产品名称 载体 规格 价格
G110376 人 RNF34 (NM_001256858) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RNF34 (NM_194271) cDNA克隆 transcript variant 1
人 RNF34 (NM_025126) cDNA克隆 transcript variant 2
人 RNF34 (NM_001256858) cDNA克隆 transcript variant 3

基因简介

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

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