人 ALOX5AP (NM_001204406) cDNA克隆

基本信息

Accession: NM_001204406
基因名称: ALOX5AP
基因别名: FLAP
基因描述: Homo sapiens arachidonate 5-lipoxygenase-activating protein (ALOX5AP), transcript variant 2, mRNA.
种属: Human
CDS区长度: 657 (查看编码区序列)
翻译后氨基酸长度: 218 (查看氨基酸序列)
Transcript Variant: This variant (2) has an alternate 5' sequence which includes an upstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) is longer at the N-terminus, as compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G113017 人 ALOX5AP (NM_001204406) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 ALOX5AP (NM_001629) cDNA克隆 transcript variant 1
人 ALOX5AP (NM_001204406) cDNA克隆 transcript variant 2

基因简介

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

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