人 NLRC4 (NM_021209) cDNA克隆

基本信息

Accession: NM_021209
基因名称: NLRC4
基因别名: CLAN; IPAF; CLAN1; CLANA; CLANB; CLANC; CLAND; CARD12; CLR2.1
基因描述: Homo sapiens NLR family, CARD domain containing 4 (NLRC4), transcript variant 1, mRNA.
种属: Human
CDS区长度: 3075 (查看编码区序列)
翻译后氨基酸长度: 1024 (查看氨基酸序列)
Transcript Variant: This variant (1) and variants 2 and 3 encode the same protein.

订购信息

产品编号 产品名称 载体 规格 价格
G113993 人 NLRC4 (NM_021209) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 NLRC4 (NM_021209) cDNA克隆 transcript variant 1
人 NLRC4 (NM_001199138) cDNA克隆 transcript variant 2
人 NLRC4 (NM_001199139) cDNA克隆 transcript variant 3

基因简介

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM, Mar 2008]

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