人 DAZ4 (NM_001005375) cDNA克隆

Accession: NM_001005375
基因名称: DAZ4
基因别名: pDP1680; pDP1681
基因描述: Homo sapiens deleted in azoospermia 4 (DAZ4), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1740 (查看编码区序列)
翻译后氨基酸长度: 579 (查看氨基酸序列)
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), which includes two RRM domains and nine DAZ repeats.
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G115543 人 DAZ4 (NM_001005375) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2011]