人 XRCC5 (NM_021141) cDNA克隆

Accession: NM_021141
基因名称: XRCC5
基因别名: KU80; KUB2; Ku86; NFIV; KARP1; KARP-1
基因描述: Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) (XRCC5), mRNA.
种属: Human
CDS区长度: 2199 (查看编码区序列)
翻译后氨基酸长度: 732 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G118204 人 XRCC5 (NM_021141) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]