This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
人 XRCC3 (NM_005432) cDNA克隆
| Accession: | NM_005432 |
|---|---|
| 基因名称: | XRCC3 |
| 基因别名: | CMM6 |
| 基因描述: | Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3), transcript variant 2, mRNA. |
| 种属: | Human |
| CDS区长度: | 1041 (查看编码区序列) |
| 翻译后氨基酸长度: | 346 (查看氨基酸序列) |
| Transcript Variant: | This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein. |
| 人 XRCC3 (NM_001100119) cDNA克隆 | transcript variant 1 |
| 人 XRCC3 (NM_005432) cDNA克隆 | transcript variant 2 |
| 人 XRCC3 (NM_001100118) cDNA克隆 | transcript variant 3 |
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