人 VNN2 (NM_004665) cDNA克隆

Accession: NM_004665
基因名称: VNN2
基因别名: FOAP-4; GPI-80
基因描述: Homo sapiens vanin 2 (VNN2), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1563 (查看编码区序列)
翻译后氨基酸长度: 520 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes the longer isoform (1) with a different N-terminus containing a leader peptide, compared to isoform 2.
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G123423 人 VNN2 (NM_004665) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]