人 CHIT1 (NM_003465) cDNA克隆

Accession: NM_003465
基因名称: CHIT1
基因别名: CHI3; CHIT; CHITD
基因描述: Homo sapiens chitinase 1 (chitotriosidase) (CHIT1), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1401 (查看编码区序列)
翻译后氨基酸长度: 466 (查看氨基酸序列)
Transcript Variant: This variant (1) is the predominant transcript and it encodes the longest isoform (1).
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G123463 人 CHIT1 (NM_003465) cDNA克隆 pDONR223 2ug质粒 点击询价

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]