人 CHIT1 (NM_001270509) cDNA克隆

基本信息

Accession: NM_001270509
基因名称: CHIT1
基因别名: CHI3; CHIT; CHITD
基因描述: Homo sapiens chitinase 1 (chitotriosidase) (CHIT1), transcript variant 5, mRNA.
种属: Human
CDS区长度: 1266 (查看编码区序列)
翻译后氨基酸长度: 421 (查看氨基酸序列)
Transcript Variant: This variant (5) lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G123465 人 CHIT1 (NM_001270509) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CHIT1 (NM_003465) cDNA克隆 transcript variant 1
人 CHIT1 (NM_001256125) cDNA克隆 transcript variant 2
人 CHIT1 (NM_001270509) cDNA克隆 transcript variant 5

基因简介

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]

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