SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002 [PubMed 12027893]).[supplied by OMIM, Mar 2008]
人 SPRY4 (NM_030964) cDNA克隆
| Accession: | NM_030964 |
|---|---|
| 基因名称: | SPRY4 |
| 基因别名: | HH17 |
| 基因描述: | Homo sapiens sprouty homolog 4 (Drosophila) (SPRY4), transcript variant 1, mRNA. |
| 种属: | Human |
| CDS区长度: | 969 (查看编码区序列) |
| 翻译后氨基酸长度: | 322 (查看氨基酸序列) |
| Transcript Variant: | This variant (1) represents the longer variant and it encodes the longer protein (isoform 1). |
| 人 SPRY4 (NM_030964) cDNA克隆 | transcript variant 1 |
| 人 SPRY4 (NM_001127496) cDNA克隆 | transcript variant 2 |
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