This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
人 TJP1 (NM_175610) cDNA克隆
| Accession: | NM_175610 |
|---|---|
| 基因名称: | TJP1 |
| 基因别名: | ZO-1 |
| 基因描述: | Homo sapiens tight junction protein 1 (TJP1), transcript variant 2, mRNA. |
| 种属: | Human |
| CDS区长度: | 5007 (查看编码区序列) |
| 翻译后氨基酸长度: | 1668 (查看氨基酸序列) |
| Transcript Variant: | This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), compared to isoform a. Isoform b is found in both endothelial cells and the highly specialized epithelial junctions of renal glomeruli and sertoli cells of the seminiferous tubules. |
| 人 TJP1 (NM_003257) cDNA克隆 | transcript variant 1 |
| 人 TJP1 (NM_175610) cDNA克隆 | transcript variant 2 |
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