小鼠 Sigmar1 (NM_001286551) cDNA克隆

基本信息

Accession: NM_001286551
基因名称: Sigmar1
基因别名: Oprs1; sigma1R; AL024364
基因描述: Mus musculus sigma non-opioid intracellular receptor 1 (Sigmar1), transcript variant 7, mRNA.
种属: Mouse
CDS区长度: 321 (查看编码区序列)
翻译后氨基酸长度: 106 (查看氨基酸序列)
Transcript Variant: This variant (7) differs in the 3' UTR and uses an alternate splice site in the coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 7; also known as short form sigma1R) is shorter and has a distinct C-terminus compared to isoform 1. This isoform negatively regulates the function of the longest isoform (1) by forming a complex with the latter (PMID 22619170). Variants 7 and 8 encode the same protein.

订购信息

产品编号 产品名称 载体 规格 价格
G134666 小鼠 Sigmar1 (NM_001286551) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

小鼠 Sigmar1 (NM_011014) cDNA克隆 transcript variant 1
小鼠 Sigmar1 (NM_001286538) cDNA克隆 transcript variant 2
小鼠 Sigmar1 (NM_001286539) cDNA克隆 transcript variant 3
小鼠 Sigmar1 (NM_001286540) cDNA克隆 transcript variant 4
小鼠 Sigmar1 (NM_001286541) cDNA克隆 transcript variant 5
小鼠 Sigmar1 (NM_001286542) cDNA克隆 transcript variant 6
小鼠 Sigmar1 (NM_001286551) cDNA克隆 transcript variant 7
小鼠 Sigmar1 (NM_001286605) cDNA克隆 transcript variant 8

基因简介

This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]

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