人 KAT6B (NM_012330) cDNA克隆

Accession: NM_012330
基因名称: KAT6B
基因别名: qkf; MORF; MOZ2; GTPTS; MYST4; ZC2HC6B; querkopf
基因描述: Homo sapiens K(lysine) acetyltransferase 6B (KAT6B), transcript variant 1, mRNA.
种属: Human
CDS区长度: 6222 (查看编码区序列)
翻译后氨基酸长度: 2073 (查看氨基酸序列)
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
产品编号 产品名称 载体 规格 价格
G140861 人 KAT6B (NM_012330) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]