人 ARHGAP8 (NM_001198726) cDNA克隆

基本信息

Accession: NM_001198726
基因名称: ARHGAP8
基因别名: PP610; BPGAP1
基因描述: Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 3, mRNA.
种属: Human
CDS区长度: 918 (查看编码区序列)
翻译后氨基酸长度: 305 (查看氨基酸序列)
Transcript Variant: This variant (3) lacks both an alternate in-frame exon in the central coding region and an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G141136 人 ARHGAP8 (NM_001198726) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 ARHGAP8 (NM_001017526) cDNA克隆 transcript variant 1
人 ARHGAP8 (NM_181335) cDNA克隆 transcript variant 2
人 ARHGAP8 (NM_001198726) cDNA克隆 transcript variant 3

基因简介

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

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