人 GABRA1 (NM_001127644) cDNA克隆

Accession: NM_001127644
基因名称: GABRA1
基因别名: EJM; ECA4; EJM5
基因描述: Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1371 (查看编码区序列)
翻译后氨基酸长度: 456 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
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G142876 人 GABRA1 (NM_001127644) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]