人 APAF1 (NM_181869) cDNA克隆

基本信息

Accession: NM_181869
基因名称: APAF1
基因别名: CED4; APAF-1
基因描述: Homo sapiens apoptotic peptidase activating factor 1 (APAF1), transcript variant 5, mRNA.
种属: Human
CDS区长度: 1017 (查看编码区序列)
翻译后氨基酸长度: 338 (查看氨基酸序列)
Transcript Variant: This variant (5), also known as APAF-1-ALT, lacks several exons in the coding sequence, resulting in a frameshift and an early termination codon compared to variant 3. Variant 5 encodes isoform e, which is shorter and has a distinct C-terminus compared to isoform c.

订购信息

产品编号 产品名称 载体 规格 价格
G148794 人 APAF1 (NM_181869) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 APAF1 (NM_013229) cDNA克隆 transcript variant 1
人 APAF1 (NM_001160) cDNA克隆 transcript variant 2
人 APAF1 (NM_181861) cDNA克隆 transcript variant 3
人 APAF1 (NM_181868) cDNA克隆 transcript variant 4
人 APAF1 (NM_181869) cDNA克隆 transcript variant 5

基因简介

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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