人 APAF1 (NM_013229) cDNA克隆

Accession: NM_013229
基因名称: APAF1
基因别名: CED4; APAF-1
基因描述: Homo sapiens apoptotic peptidase activating factor 1 (APAF1), transcript variant 1, mRNA.
种属: Human
CDS区长度: 3714 (查看编码区序列)
翻译后氨基酸长度: 1237 (查看氨基酸序列)
Transcript Variant: This variant (1) uses an alternate splice site in the coding region but maintains the reading frame, compared to variant 3. Variant 1 encodes isoform a, which is shorter than isoform c.
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G148795 人 APAF1 (NM_013229) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]