人 HNF4A (NM_001030003) cDNA克隆

基本信息

Accession: NM_001030003
基因名称: HNF4A
基因别名: TCF; HNF4; MODY; MODY1; NR2A1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; HNF4alpha
基因描述: Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 4, mRNA.
种属: Human
CDS区长度: 1329 (查看编码区序列)
翻译后氨基酸长度: 442 (查看氨基酸序列)
Transcript Variant: This variant (4) contains an alternate 5' terminal exon (resulting in translation initiation from an alternate upstream start codon) and uses an alternate in-frame donor splice site in the 3' coding region compared to variant 2. The resulting shorter isoform (HNF4alpha7) has a distinct N-terminus and lacks a 10 aa protein segment in the C-terminal region compared to isoform HNF4alpha2.

订购信息

产品编号 产品名称 载体 规格 价格
G148803 人 HNF4A (NM_001030003) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 HNF4A (NM_178849) cDNA克隆 transcript variant 1
人 HNF4A (NM_001287184) cDNA克隆 transcript variant 10
人 HNF4A (NM_000457) cDNA克隆 transcript variant 2
人 HNF4A (NM_178850) cDNA克隆 transcript variant 3
人 HNF4A (NM_001030003) cDNA克隆 transcript variant 4
人 HNF4A (NM_175914) cDNA克隆 transcript variant 5
人 HNF4A (NM_001030004) cDNA克隆 transcript variant 6
人 HNF4A (NM_001258355) cDNA克隆 transcript variant 7
人 HNF4A (NM_001287182) cDNA克隆 transcript variant 8
人 HNF4A (NM_001287183) cDNA克隆 transcript variant 9

基因简介

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

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