人 HNF4A (NM_001258355) cDNA克隆

基本信息

Accession: NM_001258355
基因名称: HNF4A
基因别名: TCF; HNF4; MODY; MODY1; NR2A1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; HNF4alpha
基因描述: Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 7, mRNA.
种属: Human
CDS区长度: 1404 (查看编码区序列)
翻译后氨基酸长度: 467 (查看氨基酸序列)
Transcript Variant: This variant (7) contains an additional coding exon in the 5' region that results in translation initiation from an alternate downstream start codon compared to variant 2. The resulting shorter isoform (HNF4alpha4) has a distinct N-terminus compared to isoform HNF4alpha2.

订购信息

产品编号 产品名称 载体 规格 价格
G148808 人 HNF4A (NM_001258355) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 HNF4A (NM_178849) cDNA克隆 transcript variant 1
人 HNF4A (NM_001287184) cDNA克隆 transcript variant 10
人 HNF4A (NM_000457) cDNA克隆 transcript variant 2
人 HNF4A (NM_178850) cDNA克隆 transcript variant 3
人 HNF4A (NM_001030003) cDNA克隆 transcript variant 4
人 HNF4A (NM_175914) cDNA克隆 transcript variant 5
人 HNF4A (NM_001030004) cDNA克隆 transcript variant 6
人 HNF4A (NM_001258355) cDNA克隆 transcript variant 7
人 HNF4A (NM_001287182) cDNA克隆 transcript variant 8
人 HNF4A (NM_001287183) cDNA克隆 transcript variant 9

基因简介

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

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