人 KCNQ3 (NM_001204824) cDNA克隆

基本信息

Accession: NM_001204824
基因名称: KCNQ3
基因别名: EBN2; BFNC2; KV7.3
基因描述: Homo sapiens potassium voltage-gated channel, KQT-like subfamily, member 3 (KCNQ3), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2259 (查看编码区序列)
翻译后氨基酸长度: 752 (查看氨基酸序列)
Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G151078 人 KCNQ3 (NM_001204824) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 KCNQ3 (NM_004519) cDNA克隆 transcript variant 1
人 KCNQ3 (NM_001204824) cDNA克隆 transcript variant 2

基因简介

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found. [provided by RefSeq, Mar 2011]

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