人 NTRK1 (NM_001007792) cDNA克隆

基本信息

Accession: NM_001007792
基因名称: NTRK1
基因别名: MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA
基因描述: Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 2283 (查看编码区序列)
翻译后氨基酸长度: 760 (查看氨基酸序列)
Transcript Variant: This variant (3) utilizes alternate 5' exons and lacks an internal in-frame exon, compared to variant 2. Translation initiation occurs at an upstream AUG, resulting in a shorter isoform (3) with a unique N-terminus compared to isoform 2.

订购信息

产品编号 产品名称 载体 规格 价格
G153032 人 NTRK1 (NM_001007792) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 NTRK1 (NM_001012331) cDNA克隆 transcript variant 1
人 NTRK1 (NM_002529) cDNA克隆 transcript variant 2
人 NTRK1 (NM_001007792) cDNA克隆 transcript variant 3

基因简介

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

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