人 SEPT4 (NM_080415) cDNA克隆

基本信息

Accession: NM_080415
基因名称: SEPT4
基因别名: H5; ARTS; MART; SEP4; CE5B3; PNUTL2; hucep-7; BRADEION; hCDCREL-2
基因描述: Homo sapiens septin 4 (SEPT4), transcript variant 2, mRNA.
种属: Human
CDS区长度: 825 (查看编码区序列)
翻译后氨基酸长度: 274 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 7. This transcript contains an early translation termination site, rendering this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, the encoded protein (isoform 2, also known as ARTS, SEPT4_i2), with distinct N- and C-termini compared to isoform 5, has been shown to be expressed in vivo, and characterized as a mitochondrial pro-apoptotic, tumor suppressor protein having a role in cancer (PMIDs: 11146656, 15254396).

订购信息

产品编号 产品名称 载体 规格 价格
G154620 人 SEPT4 (NM_080415) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SEPT4 (NM_004574) cDNA克隆 transcript variant 1
人 SEPT4 (NM_080415) cDNA克隆 transcript variant 2
人 SEPT4 (NM_080416) cDNA克隆 transcript variant 3
人 SEPT4 (NM_001198713) cDNA克隆 transcript variant 4
人 SEPT4 (NM_001256822) cDNA克隆 transcript variant 6
人 SEPT4 (NM_001256782) cDNA克隆 transcript variant 7

基因简介

This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]

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