人 PRKACA (NM_002730) cDNA克隆

Accession: NM_002730
基因名称: PRKACA
基因别名: PKACA
基因描述: Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha (PRKACA), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1056 (查看编码区序列)
翻译后氨基酸长度: 351 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes the longer isoform (1).
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G155384 人 PRKACA (NM_002730) cDNA克隆 pDONR223 2ug质粒 点击询价

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]