人 KREMEN2 (NM_001253726) cDNA克隆

基本信息

Accession: NM_001253726
基因名称: KREMEN2
基因别名: KRM2
基因描述: Homo sapiens kringle containing transmembrane protein 2 (KREMEN2), transcript variant 6, mRNA.
种属: Human
CDS区长度: 1272 (查看编码区序列)
翻译后氨基酸长度: 423 (查看氨基酸序列)
Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform f), compared to isoform d.

订购信息

产品编号 产品名称 载体 规格 价格
G165365 人 KREMEN2 (NM_001253726) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 KREMEN2 (NM_024507) cDNA克隆 transcript variant 2
人 KREMEN2 (NM_172229) cDNA克隆 transcript variant 4
人 KREMEN2 (NM_001253725) cDNA克隆 transcript variant 5
人 KREMEN2 (NM_001253726) cDNA克隆 transcript variant 6

基因简介

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

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