人 KREMEN1 (NM_001039570) cDNA克隆

Accession: NM_001039570
基因名称: KREMEN1
基因别名: KRM1; KREMEN
基因描述: Homo sapiens kringle containing transmembrane protein 1 (KREMEN1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1377 (查看编码区序列)
翻译后氨基酸长度: 458 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 2. The resulting isoform has a distinct C-terminus and is shorter than isoform 2.
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G166414 人 KREMEN1 (NM_001039570) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]