人 COL25A1 (NM_032518) cDNA克隆

基本信息

Accession: NM_032518
基因名称: COL25A1
基因别名: AMY; CLAC; CLACP; CLAC-P
基因描述: Homo sapiens collagen, type XXV, alpha 1 (COL25A1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1929 (查看编码区序列)
翻译后氨基酸长度: 642 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks three 3' exons but includes an alternate 3' exon, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G166605 人 COL25A1 (NM_032518) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 COL25A1 (NM_198721) cDNA克隆 transcript variant 1
人 COL25A1 (NM_032518) cDNA克隆 transcript variant 2
人 COL25A1 (NM_001256074) cDNA克隆 transcript variant 3

基因简介

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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