人 COL25A1 (NM_001256074) cDNA克隆

基本信息

Accession: NM_001256074
基因名称: COL25A1
基因别名: AMY; CLAC; CLACP; CLAC-P
基因描述: Homo sapiens collagen, type XXV, alpha 1 (COL25A1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1938 (查看编码区序列)
翻译后氨基酸长度: 645 (查看氨基酸序列)
Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, and also differs in the 5' and 3' UTRs, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G166607 人 COL25A1 (NM_001256074) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 COL25A1 (NM_198721) cDNA克隆 transcript variant 1
人 COL25A1 (NM_032518) cDNA克隆 transcript variant 2
人 COL25A1 (NM_001256074) cDNA克隆 transcript variant 3

基因简介

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

相关产品