人 CTIF (NM_001142397) cDNA克隆

基本信息

Accession: NM_001142397
基因名称: CTIF
基因别名: Gm672; KIAA0427
基因描述: Homo sapiens CBP80/20-dependent translation initiation factor (CTIF), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1803 (查看编码区序列)
翻译后氨基酸长度: 600 (查看氨基酸序列)
Transcript Variant: This variant (2) contains an additional 5' non-coding exon, and uses an alternate donor splice site at one of the internal coding exons compared to transcript variant 1. This results in an isoform (2) with two additional amino acids compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G167926 人 CTIF (NM_001142397) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CTIF (NM_014772) cDNA克隆 transcript variant 1
人 CTIF (NM_001142397) cDNA克隆 transcript variant 2

基因简介

CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

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