人 CTIF (NM_014772) cDNA克隆

基本信息

Accession: NM_014772
基因名称: CTIF
基因别名: Gm672; KIAA0427
基因描述: Homo sapiens CBP80/20-dependent translation initiation factor (CTIF), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1797 (查看编码区序列)
翻译后氨基酸长度: 598 (查看氨基酸序列)
Transcript Variant: This variant (1) represents the more predominant transcript and encodes isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G167927 人 CTIF (NM_014772) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CTIF (NM_014772) cDNA克隆 transcript variant 1
人 CTIF (NM_001142397) cDNA克隆 transcript variant 2

基因简介

CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

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