人 APBB1 (NM_001257323) cDNA克隆

基本信息

Accession: NM_001257323
基因名称: APBB1
基因别名: RIR; FE65; MGC:9072
基因描述: Homo sapiens amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 8, mRNA.
种属: Human
CDS区长度: 1467 (查看编码区序列)
翻译后氨基酸长度: 488 (查看氨基酸序列)
Transcript Variant: This variant (8) represents use of an alternate promoter and thus differs in the 5' UTR and 5' coding region, and lacks an alternate, in-frame exon in the coding region compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (f) that is shorter with a distinct N-terminus, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G102468 人 APBB1 (NM_001257323) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 APBB1 (NM_001164) cDNA克隆 transcript variant 1
人 APBB1 (NM_145689) cDNA克隆 transcript variant 2
人 APBB1 (NM_001257321) cDNA克隆 transcript variant 4
人 APBB1 (NM_001257326) cDNA克隆 transcript variant 5
人 APBB1 (NM_001257320) cDNA克隆 transcript variant 6
人 APBB1 (NM_001257325) cDNA克隆 transcript variant 7
人 APBB1 (NM_001257323) cDNA克隆 transcript variant 8
人 APBB1 (NM_001257319) cDNA克隆 transcript variant 9

基因简介

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

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