人 RBM14 (NM_001198836) cDNA克隆

基本信息

Accession: NM_001198836
基因名称: RBM14
基因别名: SIP; COAA; PSP2; SYTIP1; TMEM137
基因描述: Homo sapiens RNA binding motif protein 14 (RBM14), transcript variant 2, mRNA.
种属: Human
CDS区长度: 471 (查看编码区序列)
翻译后氨基酸长度: 156 (查看氨基酸序列)
Transcript Variant: This variant (2) uses an alternate donor splice site at an internal coding exon compared to variant 1. This results in a frame-shift and an isoform (2, also known as CoAM or coactivator modulator) with a distinct and shorter C-terminus compared to isoform 1. This isoform lacks the TRBP-interacting domain, and functions as a transcriptional repressor by inhibiting the activity of isoform 1 (PMID:11443112).

订购信息

产品编号 产品名称 载体 规格 价格
G104255 人 RBM14 (NM_001198836) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RBM14 (NM_006328) cDNA克隆 transcript variant 1
人 RBM14 (NM_001198836) cDNA克隆 transcript variant 2
人 RBM14 (NM_001198837) cDNA克隆 transcript variant 3

基因简介

This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

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