人 RAD51C (NM_002876) cDNA克隆

Accession: NM_002876
基因名称: RAD51C
基因别名: FANCO; R51H3; BROVCA3; RAD51L2
基因描述: Homo sapiens RAD51 paralog C (RAD51C), transcript variant 2, mRNA.
种属: Human
CDS区长度: 408 (查看编码区序列)
翻译后氨基酸长度: 135 (查看氨基酸序列)
Transcript Variant: This variant (2) uses an alternate 3' structure, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
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G107603 人 RAD51C (NM_002876) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]