人 UBE2C (NM_001281742) cDNA克隆

Accession: NM_001281742
基因名称: UBE2C
基因别名: UBCH10; dJ447F3.2
基因描述: Homo sapiens ubiquitin-conjugating enzyme E2C (UBE2C), transcript variant 8, mRNA.
种属: Human
CDS区长度: 240 (查看编码区序列)
翻译后氨基酸长度: 79 (查看氨基酸序列)
Transcript Variant: This variant (8) lacks an exon in central coding region, which results in a translational frameshift, compared to variant 1. The encoded isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.
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G107900 人 UBE2C (NM_001281742) cDNA克隆 pDONR223 2ug质粒 点击询价

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]