人 PPM1A (NM_177951) cDNA克隆

Accession: NM_177951
基因名称: PPM1A
基因别名: PP2CA; PP2Calpha; PP2C-ALPHA
基因描述: Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1A (PPM1A), transcript variant 2, mRNA.
种属: Human
CDS区长度: 975 (查看编码区序列)
翻译后氨基酸长度: 324 (查看氨基酸序列)
Transcript Variant: This variant (2) has an additional exon within the 5' UTR and lacks a few of 3' exons but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
产品编号 产品名称 载体 规格 价格
G110488 人 PPM1A (NM_177951) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]