人 RASGRP3 (NM_015376) cDNA克隆

基本信息

Accession: NM_015376
基因名称: RASGRP3
基因别名: GRP3
基因描述: Homo sapiens RAS guanyl releasing protein 3 (calcium and DAG-regulated) (RASGRP3), transcript variant 3, mRNA.
种属: Human
CDS区长度: 2070 (查看编码区序列)
翻译后氨基酸长度: 689 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G112660 人 RASGRP3 (NM_015376) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RASGRP3 (NM_001139488) cDNA克隆 transcript variant 1
人 RASGRP3 (NM_170672) cDNA克隆 transcript variant 2
人 RASGRP3 (NM_015376) cDNA克隆 transcript variant 3

基因简介

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

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