人 RASGRP1 (NM_001128602) cDNA克隆

基本信息

Accession: NM_001128602
基因名称: RASGRP1
基因别名: V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII
基因描述: Homo sapiens RAS guanyl releasing protein 1 (calcium and DAG-regulated) (RASGRP1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2289 (查看编码区序列)
翻译后氨基酸长度: 762 (查看氨基酸序列)
Transcript Variant: This variant (2), also known as variant A, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G122865 人 RASGRP1 (NM_001128602) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RASGRP1 (NM_005739) cDNA克隆 transcript variant 1
人 RASGRP1 (NM_001128602) cDNA克隆 transcript variant 2

基因简介

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

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