人 PAK7 (NM_020341) cDNA克隆

Accession: NM_020341
基因名称: PAK7
基因别名: PAK5
基因描述: Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 7 (PAK7), transcript variant 1, mRNA.
种属: Human
CDS区长度: 2160 (查看编码区序列)
翻译后氨基酸长度: 719 (查看氨基酸序列)
Transcript Variant: This variant (1) represents the longer transcript. This variant and variant 2 encode the same protein.
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G113750 人 PAK7 (NM_020341) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]