人 CARD8 (NM_001184903) cDNA克隆

基本信息

Accession: NM_001184903
基因名称: CARD8
基因别名: NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
基因描述: Homo sapiens caspase recruitment domain family, member 8 (CARD8), transcript variant 5, mRNA.
种属: Human
CDS区长度: 1179 (查看编码区序列)
翻译后氨基酸长度: 392 (查看氨基酸序列)
Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).

订购信息

产品编号 产品名称 载体 规格 价格
G117427 人 CARD8 (NM_001184903) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CARD8 (NM_001184900) cDNA克隆 transcript variant 1
人 CARD8 (NM_014959) cDNA克隆 transcript variant 2
人 CARD8 (NM_001184901) cDNA克隆 transcript variant 3
人 CARD8 (NM_001184902) cDNA克隆 transcript variant 4
人 CARD8 (NM_001184903) cDNA克隆 transcript variant 5
人 CARD8 (NM_001184904) cDNA克隆 transcript variant 6

基因简介

The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

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