人 CARD8 (NM_001184904) cDNA克隆

基本信息

Accession: NM_001184904
基因名称: CARD8
基因别名: NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
基因描述: Homo sapiens caspase recruitment domain family, member 8 (CARD8), transcript variant 6, mRNA.
种属: Human
CDS区长度: 213 (查看编码区序列)
翻译后氨基酸长度: 70 (查看氨基酸序列)
Transcript Variant: This variant (6) differs in the 5' UTR, 3' coding region, and 3' UTR compared to variant 1. The resulting isoform (d) is shorter than isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G117428 人 CARD8 (NM_001184904) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CARD8 (NM_001184900) cDNA克隆 transcript variant 1
人 CARD8 (NM_014959) cDNA克隆 transcript variant 2
人 CARD8 (NM_001184901) cDNA克隆 transcript variant 3
人 CARD8 (NM_001184902) cDNA克隆 transcript variant 4
人 CARD8 (NM_001184903) cDNA克隆 transcript variant 5
人 CARD8 (NM_001184904) cDNA克隆 transcript variant 6

基因简介

The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

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