人 RAD18 (NM_020165) cDNA克隆

Accession: NM_020165
基因名称: RAD18
基因别名: RNF73
基因描述: Homo sapiens RAD18 homolog (S. cerevisiae) (RAD18), mRNA.
种属: Human
CDS区长度: 1488 (查看编码区序列)
翻译后氨基酸长度: 495 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G118067 人 RAD18 (NM_020165) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]