人 MAP3K7 (NM_145332) cDNA克隆

基本信息

Accession: NM_145332
基因名称: MAP3K7
基因别名: TAK1; MEKK7; TGF1a
基因描述: Homo sapiens mitogen-activated protein kinase kinase kinase 7 (MAP3K7), transcript variant C, mRNA.
种属: Human
CDS区长度: 1557 (查看编码区序列)
翻译后氨基酸长度: 518 (查看氨基酸序列)
Transcript Variant: This variant (C) lacks a segment, which leads to a frameshift, compared to variant B. The resulting isoform (C) contains a distinct and shorter C-terminus, as compared to isoform B.

订购信息

产品编号 产品名称 载体 规格 价格
G118110 人 MAP3K7 (NM_145332) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 MAP3K7 (NM_003188) cDNA克隆 transcript variant A
人 MAP3K7 (NM_145331) cDNA克隆 transcript variant B
人 MAP3K7 (NM_145332) cDNA克隆 transcript variant C
人 MAP3K7 (NM_145333) cDNA克隆 transcript variant D

基因简介

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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