人 KRT80 (NM_182507) cDNA克隆

Accession: NM_182507
基因名称: KRT80
基因别名: KB20
基因描述: Homo sapiens keratin 80 (KRT80), transcript variant 1, mRNA.
种属: Human
CDS区长度: 1359 (查看编码区序列)
翻译后氨基酸长度: 452 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes the longer isoform (K80, also known as a).
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G119406 人 KRT80 (NM_182507) cDNA克隆 pDONR223 2ug质粒 点击询价

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.[provided by RefSeq, Oct 2010]