人 SMG6 (NM_001282326) cDNA克隆

基本信息

Accession: NM_001282326
基因名称: SMG6
基因别名: EST1A; SMG-6; C17orf31; hSMG5/7a
基因描述: Homo sapiens SMG6 nonsense mediated mRNA decay factor (SMG6), transcript variant 5, mRNA.
种属: Human
CDS区长度: 993 (查看编码区序列)
翻译后氨基酸长度: 330 (查看氨基酸序列)
Transcript Variant: This variant (5) uses an alternate internal promoter and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at an alternate AUG, and the resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G120189 人 SMG6 (NM_001282326) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SMG6 (NM_017575) cDNA克隆 transcript variant 1
人 SMG6 (NM_001256827) cDNA克隆 transcript variant 3
人 SMG6 (NM_001256828) cDNA克隆 transcript variant 4
人 SMG6 (NM_001282326) cDNA克隆 transcript variant 5

基因简介

This gene encodes a protein which is part of the telomerase ribonucleoprotein complex and binds single-stranded DNA found at the telomeres, but the product of this gene also participates in the nonsense-mediated mRNA decay (NMD) pathway. The encoded protein contains two binding sites for components of the exon junction complex (EJC); interaction between the encoded protein and the EJC is necessary for NMD activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

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