人 SMG7 (NM_001174061) cDNA克隆

基本信息

Accession: NM_001174061
基因名称: SMG7
基因别名: EST1C; SGA56M; C1orf16
基因描述: Homo sapiens SMG7 nonsense mediated mRNA decay factor (SMG7), transcript variant 5, mRNA.
种属: Human
CDS区长度: 3438 (查看编码区序列)
翻译后氨基酸长度: 1145 (查看氨基酸序列)
Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G121143 人 SMG7 (NM_001174061) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SMG7 (NM_173156) cDNA克隆 transcript variant 1
人 SMG7 (NM_201568) cDNA克隆 transcript variant 2
人 SMG7 (NM_201569) cDNA克隆 transcript variant 4
人 SMG7 (NM_001174061) cDNA克隆 transcript variant 5

基因简介

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

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