大鼠 Adarb1 (NM_001111057) cDNA克隆

基本信息

Accession: NM_001111057
基因名称: Adarb1
基因别名: Red1; Adar2
基因描述: Rattus norvegicus adenosine deaminase, RNA-specific, B1 (Adarb1), transcript variant 4, mRNA.
种属: Rat
CDS区长度: 2034 (查看编码区序列)
翻译后氨基酸长度: 677 (查看氨基酸序列)
Transcript Variant: This variant (4, also referred to as 2e) results from an auto RNA editing event (AA->AI) in the intronic sequence that creates a novel acceptor splice site, splicing to which inserts 47 nt into the coding region causing a frame-shift, compared to transcript variant 2. Translation initiation from the upstream AUG will result in a very short protein of 82 aa. However, studies reported in PMID:10331393 show that leaky translation initiation from an in-frame, downstream AUG allows some protein expression, and that this isoform (3) exhibits RNA editing activity. Isoform 4 is 24 aa shorter at the N-terminus compared to isoform 2.

订购信息

产品编号 产品名称 载体 规格 价格
G142743 大鼠 Adarb1 (NM_001111057) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

大鼠 Adarb1 (NM_012894) cDNA克隆 transcript variant 1
大鼠 Adarb1 (NM_001111055) cDNA克隆 transcript variant 2
大鼠 Adarb1 (NM_001111056) cDNA克隆 transcript variant 3
大鼠 Adarb1 (NM_001111057) cDNA克隆 transcript variant 4

基因简介

This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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