人 SHMT2 (NM_001166359) cDNA克隆

基本信息

Accession: NM_001166359
基因名称: SHMT2
基因别名: GLYA; SHMT
基因描述: Homo sapiens serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), transcript variant 5, mRNA.
种属: Human
CDS区长度: 1452 (查看编码区序列)
翻译后氨基酸长度: 483 (查看氨基酸序列)
Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, and 5 encode the same isoform 3. Translation efficiency is uncertain from this alternative start codon, and there is rapid turnover of the mitochondrial protein in the cytoplasm prior to mitochondrial import due to its shortened import presequence (PMID 8999870).

订购信息

产品编号 产品名称 载体 规格 价格
G102175 人 SHMT2 (NM_001166359) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SHMT2 (NM_005412) cDNA克隆 transcript variant 1
人 SHMT2 (NM_001166356) cDNA克隆 transcript variant 2
人 SHMT2 (NM_001166357) cDNA克隆 transcript variant 3
人 SHMT2 (NM_001166358) cDNA克隆 transcript variant 4
人 SHMT2 (NM_001166359) cDNA克隆 transcript variant 5

基因简介

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

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